Sirt3 restricts tumor initiation via promoting LONP1 deacetylation and K63 ubiquitination.

Liyi WuXinyi YanRuibo SunYe MaWanyu YaoBaogui GaoQingyuan ZhangJunxiong YouHao WangQinrui HanXue-Gang Sun

Published in: Journal of translational medicine (2023)

Sirt3 represents a targetable metabolic checkpoint of oncogenesis, which produces energy restriction effects via maintaining LONP1 K145 deacetylation and subsequent K63 ubiquitination.

Keyphrases

oxidative stress
ischemia reperfusion injury
dna damage
cell cycle
cell proliferation