Phenome-wide association study in adult coeliac disease: role of HLA subtype.

Carolin Victoria SchneiderMoritz KleinjansMalin FrommeKai Markus SchneiderPavel Strnad

Published in: Alimentary pharmacology & therapeutics (2020)

Our data suggest that the increased mortality from lymphoproliferative diseases is restricted to those coeliac patients with 2 HLADQ2/8 alleles and that a combination of coeliac disease and HLADQ2/8 alleles is needed to increase the susceptibility. Once confirmed, closer monitoring may be warranted in this high-risk subpopulation.

Keyphrases

epstein barr virus
cardiovascular events
electronic health record
type diabetes
big data
risk factors
machine learning
coronary artery disease
young adults