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Age-Related Changes in Vancomycin Protein Binding: Is It Time to Take It Seriously?

Jessica GadsbyLucy StachowHussain Mulla
Published in: Therapeutic drug monitoring (2024)
The fraction of free unbound VAN is higher in sick children and neonates than in adults. Therefore, total VAN concentrations do not correlate with the pharmacologically active free VAN concentrations in the same manner as in adults. Adjusting VAN doses in neonates and children to target the same total VAN concentration as the recommended therapeutic range for adults may result in toxicfree concentrations.
Keyphrases
  • young adults
  • low birth weight
  • binding protein
  • staphylococcus aureus
  • small molecule
  • dna binding