Cancer of Unknown Primary Presenting as Bone-Predominant or Lymph Node-Only Disease: A Clinicopathologic Portrait.
Ryan W HueyBrandon G SmagloJeannelyn S EstrellaAurelio MatamorosMichael J OvermanGauri R VaradhacharyKanwal P S RaghavPublished in: The oncologist (2021)
Cancer of unknown primary (CUP) rarely presents as bone-predominant (BCUP) or lymph node-only (LNCUP) disease. This article describes a cohort of each and compares with a larger CUP cohort. Patients with BCUP have unique issues with fractures and pain, often receiving radiation. Overall survival of 14.5 months was similar to a larger CUP comparison cohort. Patients with LNCUP had improved overall survival at 32.6 months, with longer survival in patients without disseminated disease. Culine poor-risk group and neutrophil-to-lymphocyte ratio were associated with worse overall survival. Tips regarding diagnosis and management of these rare malignant subsets are provided.
Keyphrases
- lymph node
- papillary thyroid
- free survival
- end stage renal disease
- bone mineral density
- newly diagnosed
- squamous cell
- chronic pain
- ejection fraction
- neoadjuvant chemotherapy
- prognostic factors
- chronic kidney disease
- pain management
- soft tissue
- early stage
- radiation therapy
- body composition
- patient reported outcomes
- breast cancer risk