Hyperlipidemic microenvironment conditionates damage mechanisms in human chondrocytes by oxidative stress.

Daniel Medina-LunaMónica Guadalupe Santamaría-OlmedoYessica Zamudio-CuevasKarina Martínez-FloresJavier Fernández-TorresGabriela Angélica Martínez-NavaDenise Clavijo-CornejoCristina Hernández-DíazAnell Olivos-MezaLuis Enrique Gomez-QuirozMaría Concepción Gutiérrez-RuizCarlos PinedaFrancisco BlancoAnthony M ReginatoAlberto Gabriel López-Reyes

Published in: Lipids in health and disease (2017)

In our in vitro model of HC, a hyperlipidemia microenvironment induces an oxidative stress state that enhances the inflammatory process mediated by adipokines secretion in HC.

Keyphrases

oxidative stress
stem cells
diabetic rats
dna damage
ischemia reperfusion injury
endothelial cells
induced apoptosis
high fat diet
induced pluripotent stem cells
type diabetes
metabolic syndrome
skeletal muscle
extracellular matrix
insulin resistance