Oral Exposure to ZnO Nanoparticles Disrupt the Structure of Bone in Young Rats via the OPG/RANK/RANKL/IGF-1 Pathway.

Xinyue XuYizhou TangYuanyuan LangYanling LiuWenshu ChengHengyi XuYang Liu

Published in: International journal of nanomedicine (2020)

We infer that ZnO NPs affect bone growth in young rats directly or indirectly by altering IGF-1 levels. Overall, the results indicate that ZnO NPs promote osteoclast activity and increase bone loss through the OPG/RANK/RANKL/IGF-1 pathway.

Keyphrases

bone loss
room temperature
quantum dots
pi k akt
binding protein
reduced graphene oxide
growth hormone
visible light
middle aged
light emitting
signaling pathway
cell proliferation
gold nanoparticles
inflammatory response
bone mineral density
postmenopausal women
body composition
bone regeneration