Aberrant DNA methylation in the PAX2 promoter is associated with Müllerian duct anomalies.

Chao WangQiong XingBing SongGuanjian LiZuying XuTianjuan WangYujie ChenYuping XuYunxia Cao

Published in: Archives of gynecology and obstetrics (2020)

Aberrant DNA methylation within the promoter of PAX2 may contribute to the development of MDA by regulating its gene expression. However, the methylation status of HOXA10, EMX2, TP63, ITGB3, LHX1, GSC, WNT4, and H19, may not contribute to the development of MDA.

Keyphrases

dna methylation
gene expression
genome wide
breast cancer cells
stem cells
copy number
long non coding rna
cell cycle arrest
signaling pathway