A suite of genome-engineered hepatic cells provide novel insights into the spatiotemporal metabolism of APOB and APOB-containing lipoprotein secretion.

Amber MeursKlevis NdojMarlene van den BergGoran MarinkovićMatteo TantucciTineke VeenendaalJan Albert KuivenhovenJudith KlumpermanNoam Zelcer

Published in: Cardiovascular research (2024)

In summary, the engineered cells reported here allow the study of hepatic VLDL assembly and secretion, and facilitate spatiotemporal interrogation induced by pharmacologic and genetic perturbations.

Keyphrases

induced apoptosis
cell cycle arrest
genome wide
endoplasmic reticulum stress
cell death
oxidative stress
signaling pathway
gene expression
cell proliferation