HMGN5 Escorts Oncogenic STAT3 Signaling by Regulating the Chromatin Landscape in Breast Cancer Tumorigenesis.

Jiahui Mou Meijun Huang Feifei Wang Xiaoding Xu Hanqi Xie Henglei Lu Mingyang Li Yu Li Weiwen Kong Jing Chen Ying Xiao Yi-Ding Chen Chaochen Wang Jin Ren

Published in: Molecular cancer research : MCR (2022)

Our findings reveal a novel feed-forward circuit between HMGN5 and STAT3 in promoting breast cancer tumorigenesis and suggest HMGN5 as a novel epigenetic therapeutic target in STAT3-hyperactive breast cancer.

Keyphrases

cell proliferation
gene expression
genome wide
transcription factor
dna methylation
single cell
young adults
oxidative stress
childhood cancer