BODIPY as Multifunctional Theranostic Reagent in Biomedicine: Self-Assembly, Properties and Applications.

The outline of the review is as follows. In Section 2, the synthesis and regulatory strategies for BODIPY are summarized, and inspiring cutting-edge work in post-functionalization strategies is highlighted. Section 3 gives a brief overview of assembly model of BODIPY. In this section, we introduce BODIPY as a promising building block for the formation of single- and multi-component self-assembled systems, including nanostructures suitable for aqueous environments, thereby showing the great development potential of supramolecular assembly in biomedicine applications. Section 4 describes the frontier progress of BODIPY in biomedical applications. This section reviews examples of the frontiers of biomedical applications of BODIPY-containing smart materials. It mainly involves the application of materials based on BODIPY building blocks and their assemblies in fluorescence bioimaging, PAI, disease treatment including PDT, PTT and immunotherapy. In Section 5, not only the current status of the BODIPY family in the biomedical field but also the challenges worth considering are summarized. At the same time, it also provides insights into the future development prospects of biomedically applicable BODIPY. This article is protected by copyright. All rights reserved.