Endothelium-specific SIRT7 targeting ameliorates pulmonary hypertension through Krüpple-like factor 4 deacetylation.

Jin ZhangChenzhong XuXiaolong TangShimin SunSiqi LiuLangmei YangYuqin ChenQifeng YangTong-You Wade WeiXiaojing WuJian WangChen WangXiaosong YanLei YangYanqin NiuDeming Gou John Y-J Shyy Bao-Hua Liu

Published in: Cardiovascular research (2024)

The SIRT7/KLF4 axis ensures PAEC homeostasis, and pulmonary endothelium-specific SIRT7 targeting might constitute a PH therapeutic strategy.

Keyphrases

pulmonary hypertension
oxidative stress
ischemia reperfusion injury
nitric oxide
cancer therapy
pulmonary arterial hypertension
transcription factor
mouse model
drug delivery
coronary artery