All eyes on a phosphatase in glioma stem cells.
Robert A LindquistWilliam A WeissPublished in: The Journal of experimental medicine (2021)
In this issue of JEM, Zhang et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20202669) identify a dependency of glioma stem cells on tyrosine phosphatase activity of EYA2 and a new role for this phosphatase at the centrosome, offering a new therapeutic approach to target mitotic activity.