Inhibition of JAK2 Suppresses Myelopoiesis and Atherosclerosis in Apoe-/- Mice.

Yang TangWenli LiuWei WangTrevor FidlerBritany WoodsRoss L LevineAlan R TallNan Wang

Published in: Cardiovascular drugs and therapy (2020)

Selective JAK2 inhibition reduces atherogenesis by suppressing excessive myelopoiesis in hypercholesterolemic Apoe-/- mice. These findings suggest selective JAK2 inhibition as a potential therapeutic approach to decrease ACD risk in patients with increased myelopoiesis and leukocytosis.

Keyphrases

high fat diet induced
high fat diet
cardiovascular disease
adipose tissue
weight gain
metabolic syndrome
insulin resistance
body mass index
skeletal muscle
mild cognitive impairment