GWAS meta-analysis of 16 790 patients with Barrett's oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level.
Julia SchröderLaura ChegwiddenCarlo MajJan GehlenJan SpellerAnne C BöhmerOleg BorisovTimo HessNicole KreuserMarino VeneritoHakan AlakusAndrea MayChristian GergesThomas SchmidtRene ThiemeDominik HeiderAxel M HillmerJulian ReingruberOrestis LyrosArne DietrichAlbrecht HoffmeisterMatthias MehdornFlorian LordickGertraud StockerMichael HohausDaniel ReimJennis KandlerMichaela MüllerAlanna EbigboClaudia FuchsChristiane J BrunsArnulf H HölscherHauke LangPeter P GrimmingerDani DakkakYogesh VashistSandra MaySiegfried GörgAndre FrankeDavid EllinghausSara GalavottiLothar VeitsJosef WeismüllerJens DommermuthUdo BennerThomas RöschHelmut MessmannBrigitte SchumacherHorst NeuhausCarsten SchmidtThaddäus T WissinowskiMarkus M Nöthennull nullnull nullnull nullJing DongJue-Sheng OngMatthew F BuasAaron P ThriftThomas L VaughanIan TomlinsonDavid C WhitemanRebecca Claire FitzgeraldJanusz JankowskiMichael ViethAndreas MayrPuya GharahkhaniStuart MacGregorInes GockelClaire PallesJohannes SchumacherPublished in: Gut (2022)
Our findings provide further insights into BE/EA aetiology and its relationship to risk factors. The results lay the foundation for future follow-up studies to identify underlying disease mechanisms and improving risk prediction.