Cysteine-rich protein 2 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in mice.
Chung-Huang ChenHua-Hui HoWei-Cheng JiangWai-Sam Ao-IeongJane WangAlexander N OrekhovIgor A SobeninMatthew D LayneShaw-Fang YetPublished in: Journal of biomedical science (2022)
Our results indicate that in response to Ang II stimulation, CRP2 deficiency maintains aortic VSMC density, ECM homeostasis, and structural integrity through Erk1/2-Col III and MMP2 axis and reduces AAA formation. Thus, targeting CRP2 provides a potential therapeutic strategy for AAA.
Keyphrases
- angiotensin ii
- abdominal aortic aneurysm
- angiotensin converting enzyme
- vascular smooth muscle cells
- high glucose
- replacement therapy
- aortic valve
- diabetic rats
- cell proliferation
- left ventricular
- high fat diet induced
- cancer therapy
- pulmonary artery
- fluorescent probe
- protein protein
- amino acid
- extracellular matrix
- binding protein
- metabolic syndrome
- living cells
- drug delivery
- adipose tissue
- coronary artery
- endothelial cells
- pulmonary hypertension
- small molecule
- aortic dissection
- insulin resistance
- atrial fibrillation
- wild type