The Role of Bone Grafts in Preventing Medication-Related Osteonecrosis of the Jaw: Histomorphometric, Immunohistochemical, and Clinical Evaluation in Animal Model.

Jonathan Ribeiro da SilvaMaria Cristina de Moraes BalbasCaroline Águeda CorrêaManuella ZanelaRoberta OkamotoRodrigo Dos Santos Pereira Nicolas HomsiEduardo Hochuli-Vieira

Published in: Craniomaxillofacial trauma & reconstruction (2021)

Greater formation of bone tissue and fewer bone lacunae were found in animals treated with β-TCP. In clinical evaluation, bone graft groups presented with the clinical manifestation of MRONJ and showed higher intensity of immunostaining for TRAP and RANKL. Despite the limitations of experimental animal studies, the results of this work may assist in the development of future clinical research for the prevention of MRONJ.

Keyphrases

clinical evaluation
bone mineral density
bone loss
soft tissue
bone regeneration
high intensity
current status
adverse drug
drug induced