Abnormal spindle-like microcephaly-associated (ASPM) gene expression in posterior fossa brain tumors of childhood and adolescence.
Débora Cabral de Carvalho CorrêaIndhira Dias OliveiraBruna Mascaro CordeiroFrederico Adolfo SilvaMaria Teresa de Seixas AlvesNasjla Saba-SilvaAndrea Maria CapellanoPatrícia DastoliSergio CavalheiroSilvia Regina Caminada ToledoPublished in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2020)
Taking in account that ASPM gene has several functions to support cell proliferation, as mitotic defects and premature differentiation, we suggest that its overexpression, presumably, plays a critical role in disease progression of posterior fossa brain tumors of childhood and adolescence.