ADAMTS13 protease or lack of von Willebrand factor protects irradiation and melanoma-induced thrombotic microangiopathy in zebrafish.

Published in: Journal of thrombosis and haemostasis : JTH (2022)

Our results indicated that plasma ADAMTS13 or lack of VWF may offer a significant protection against the development of irradiation- and/or melanoma-induced TMA. Such a microenvironment may directly affect melanoma cell phenotypes via alternation in the oxidation-reduction and lipid metabolic pathways.

Keyphrases

high glucose
diabetic rats
skin cancer
stem cells
single cell
oxidative stress
cell therapy
endothelial cells
hydrogen peroxide
radiation induced
radiation therapy
electron transfer