Effects of Fluorescent Diamond Particles FDP-NV-800nm on Essential Biochemical Functions of Primary Human Umbilical Vein Cells and Human Hepatic Cell Line, HepG-2 in vitro (Part VI): Acute Biocompatibility Studies.
Cezary MarcinkiewiczPeter I LelkesMark SternbergGiora Z FeuersteinPublished in: Nanotechnology, science and applications (2020)
Our data suggest that FDP-NV-800nm are largely biocompatible with HepG-2 cells proliferation within the pharmacokinetic data reported previously. In contrast, HUVEC proliferation at the highest exposure dose (0.1 mg/mL) responded adversely with respect to several biomarkers of cell integrity. However, since the Cmax levels are very short-living, the risk for endothelial injury is likely minimal for slow rate cell proliferation such as endothelial cells.
Keyphrases
- drug delivery
- endothelial cells
- cell proliferation
- signaling pathway
- electronic health record
- induced apoptosis
- high glucose
- photodynamic therapy
- liver failure
- big data
- cell cycle arrest
- magnetic resonance
- vascular endothelial growth factor
- single cell
- quantum dots
- respiratory failure
- pi k akt
- cell cycle
- magnetic resonance imaging
- machine learning
- stem cells
- drug induced
- oxidative stress
- ionic liquid
- data analysis
- endoplasmic reticulum stress
- induced pluripotent stem cells
- bone marrow
- mesenchymal stem cells
- case control
- mechanical ventilation
- computed tomography
- breast cancer risk