Nocturnal asthma is affected by genetic interactions between RORA and NPSR1.
Vincent D GaertnerSven MichelJohn A CurtinVille PulkkinenNathalie AcevedoCilla SöderhällAndrea von BergAlbrecht BufeOtto LaubErnst RietschelAndrea HeinzmannBurkhard SimmaChristian VogelbergGöran PershagenErik MelénAngela SimpsonAdnan CustovicJuha KereMichael KabeschPublished in: Pediatric pulmonology (2019)
RORA* NPSR1 interactions appear to be involved in mechanisms specific for nocturnal asthma. In contrast to previous studies focusing on the role of beta 2 receptor polymorphisms in nocturnal asthma as a feature of asthma control or severity in general, our data suggest that changes in circadian rhythm control are associated with nighttime asthma symptoms.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- allergic rhinitis
- blood pressure
- obstructive sleep apnea
- sleep quality
- magnetic resonance
- sleep apnea
- machine learning
- cystic fibrosis
- gene expression
- computed tomography
- deep learning
- genome wide
- heart rate
- depressive symptoms
- big data
- binding protein
- artificial intelligence
- data analysis