Cyclocarya paliurus (Batal.) Ijinskaja Aqueous Extract (CPAE) Ameliorates Obesity by Improving Insulin Signaling in the Hypothalamus of a Metabolic Syndrome Rat Model.
Guangyuan XuHisae YoshitomiWen SunXuan GuoLili WuXiangyu GuoLingling QinYixin FanTunhai XuTong-Hua LiuMing GaoPublished in: Evidence-based complementary and alternative medicine : eCAM (2017)
CPAE has antiobesity, antihypoglycemic, antihypolipidemic, and antioxidant properties. The mechanism responsible for the antiobesity effect of CPAE may be related to suppression of energy intake via regulation of insulin-signaling pathway in the hypothalamus.
Keyphrases
- metabolic syndrome
- type diabetes
- insulin resistance
- signaling pathway
- oxidative stress
- glycemic control
- anti inflammatory
- weight gain
- pi k akt
- uric acid
- weight loss
- epithelial mesenchymal transition
- cardiovascular risk factors
- mouse model
- high fat diet induced
- induced apoptosis
- ionic liquid
- cardiovascular disease
- adipose tissue
- physical activity
- endoplasmic reticulum stress