The severity of neuropsychiatric symptoms is higher in early-onset than late-onset Alzheimer's Disease.

Neus FalgàsIsabel E AllenSalvatore SpinaHarli GrantStefanie D Piña EscuderoJennifer MerrileesRosalie GearhartHoward J RosenJoel H KramerWilliam W SeeleyThomas C NeylanBruce L MillerGil D RabinoviciLea Tenenholz GrinbergChristine M Walsh

Published in: European journal of neurology (2021)

Anxiety, nighttime behaviors and motor disturbances are more severe in EOAD than LOAD across the disease course. The differential patterns of neuropsychiatric symptoms observed between EOAD/LOAD could suggest a pattern of selective vulnerability extending to the brain's subcortical structures. Further, co-pathologies such as AGD in LOAD may also play a role in increasing neuropsychiatric symptoms.

Keyphrases

early onset
late onset
sleep quality
white matter
climate change
high resolution
cognitive decline
resting state
functional connectivity
cerebral ischemia