Discovery of antifungal secondary metabolites from an intestinal fungus Fusarium sp.
Mingkai ZhangBaosong ChenHuanqin DaiJingzu SunHong-Wei LiuJunjie HanPublished in: The Journal of antibiotics (2023)
Intestinal fungi, which are important parts of the gut microbiota, have the ability to produce specialized metabolites that significantly contribute to maintaining the balance of the gut microbiota and promoting the health of the host organism. In the present study, two new glycosides, including fusintespyrone A (1) and cerevisterolside A (4), as well as ten known compounds were isolated from the intestinal fungus Fusarium sp. LE06. The structures of the new compounds were elucidated by a combination of spectroscopic methods, such as mass spectrometry (MS) and nuclear magnetic resonance (NMR), along with chemical reactions and calculations of NMR and ECD spectra. Compounds 1-3 showed significant growth inhibition against Aspergillus fumigatus, Fusarium oxysporum, and Verticillium dahliae with MIC values in the range of 1.56-6.25 μg ml -1 .
Keyphrases
- magnetic resonance
- mass spectrometry
- high resolution
- ms ms
- density functional theory
- healthcare
- public health
- liquid chromatography
- solid state
- mental health
- multiple sclerosis
- small molecule
- molecular dynamics
- molecular dynamics simulations
- molecular docking
- magnetic resonance imaging
- contrast enhanced
- candida albicans
- high throughput
- computed tomography
- health information
- social media
- health promotion
- monte carlo