Large Animal Translational Validation of 3 Mitral Valve Repair Operations for Mitral Regurgitation Using a Mitral Valve Prolapse Model: A Comprehensive In Vivo Biomechanical Engineering Analysis.
Yuanjia ZhuShin YajimaMatthew H ParkAkshay VenkateshCharles J StarkNicholas A TranSabrina K WalshSidarth EthirajRobert J WilkersonLuca E LinSeung Hyun LeeKate Y GatesJustin D ArthurSam W BakerDanielle M MullisCatherine A WuShun HarimaBipul PokhrelDominique ResuelloHunter BergamascoMatthew A WuBasil M BaccouchePearly K PandyaStefan EldeHanjay WangYiping Joseph WooPublished in: Circulation. Cardiovascular interventions (2024)
Significant biomechanical differences were observed underlying different mitral repair techniques in a translational large animal model. Neochord repair was associated with the lowest primary chordae peak force compared to the remodeling and triangular resectional techniques. Additionally, neochord repair using at least 4 neochordae was associated with lower chordal forces on the primary chordae and the neochordae. This study provided key insights about mitral valve repair optimization and may further improve repair durability.