A Phase I and Surgical Study of Ribociclib and Everolimus in Children with Recurrent or Refractory Malignant Brain Tumors: A Pediatric Brain Tumor Consortium Study.
Mariko D DeWireChristine FullerOlivia CampagneTong LinHaitao PanT Young PoussaintPatricia A BaxterEugene I HwangAndrew BukowinskiKathleen DorrisLindsey HoffmanAngela J WaandersMatthias A KarajannisClinton F StewartArzu Onar-ThomasMaryam FouladiIra J DunkelPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Ribociclib and everolimus were well-tolerated and demonstrated pharmacokinetic properties similar to those in adults. Potential therapeutic ribociclib concentrations could be achieved in CSF and tumor tissue, although interpatient variability was observed.
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