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Association of iron homeostasis biomarkers in type 2 diabetes and glycaemic traits: a bidirectional two-sample Mendelian randomization study.

Ying LiangShan LuoTommy Hon Ting WongBaoting HeC Mary SchoolingShiu Lun Ryan Au Yeung
Published in: International journal of epidemiology (2023)
It is unlikely that ferritin, TSAT and TIBC cause T2D although an association for serum iron could not be excluded. Glycaemic traits and liability to T2D may affect iron homeostasis, but mediation by hepcidin is unlikely. Corresponding mechanistic studies are warranted.
Keyphrases
  • type diabetes
  • iron deficiency
  • genome wide
  • glycemic control
  • insulin resistance
  • metabolic syndrome
  • skeletal muscle
  • depressive symptoms
  • adipose tissue
  • case control