Negative correlation between endoglin levels and coronary atherosclerosis.
Haibin ChenYiping WangBing SunXunxia BaoYu TangFeifei HuangSibo ZhuJiahong XuPublished in: Lipids in health and disease (2021)
The endoglin gene in vascular endothelial cells regulates the PI3K-Akt, Wnt, TNF, and cellular metabolism pathways by activating the SMAD pathway. RAB26, MR1, CCL2, SLC29A4, IBTK, VEGFB, and GOLGA8B play critical roles. Endoglin interacts closely with 11 proteins such as CCL2 and SEPRINE1, which participate in the vital pathway of plaque formation. Interference with endoglin can alter the course of coronary atherosclerosis.
Keyphrases
- coronary artery disease
- endothelial cells
- coronary artery
- cardiovascular disease
- liver injury
- liver fibrosis
- stem cells
- rheumatoid arthritis
- epithelial mesenchymal transition
- signaling pathway
- transforming growth factor
- genome wide
- aortic stenosis
- heart failure
- drug induced
- computed tomography
- vascular endothelial growth factor
- high glucose
- transcription factor
- left ventricular
- transcatheter aortic valve replacement