Primary mitochondrial diseases: The intertwined pathophysiology of bioenergetic dysregulation, oxidative stress and neuroinflammation.

Kevin AguilarPatrycja JakubekAntonio ZorzanoMariusz Roman Wieckowski

Published in: European journal of clinical investigation (2024)

In summary, this review provides a comprehensive overview of bioenergetic alterations and redox imbalance in cellular models of PMDs while underscoring the significance of neuroinflammation as a potential driver in disease progression.

Keyphrases

oxidative stress
lipopolysaccharide induced
lps induced
traumatic brain injury
cognitive impairment
cerebral ischemia
dna damage
inflammatory response
diabetic rats
ischemia reperfusion injury
induced apoptosis
electron transfer
heat shock