Irreversible electroporation of localised prostate cancer downregulates immune suppression and induces systemic anti-tumour T-cell activation - IRE-IMMUNO study.
Bart GeboersMatthijs J V ScheltemaJason JungJoyce BakkerFlorentine E F TimmerXanthe CeruttiAthos KatelarisPaul DoanWilliam GondoputroAlexandar BlazevskiShikha AgrawalJayne MatthewsAnne-Maree HaynesTim RobertsonJames E ThompsonMartijn R MeijerinkSusan J ClarkTanja D de GruijlPhillip D StrickerPublished in: BJU international (2024)
Irreversible electroporation induces a PCa-specific systemic immune response in patients with localised PCa, aiding conversion of the tumour microenvironment into a more immune permissive state. Therapeutic efficacy might be further enhanced by combination with CTLA-4 checkpoint inhibition, potentially opening up a new synergistic treatment paradigm for high-risk localised or (oligo)metastatic disease.