Role of Deleterious Rare Alleles for Acute-Onset Diffuse Interstitial Lung Disease in Collagen Diseases.
Hiroshi FurukawaShomi OkaKota ShimadaAtsushi HashimotoAkiko KomiyaToshihiro MatsuiShigeto TohmaPublished in: Clinical medicine insights. Circulatory, respiratory and pulmonary medicine (2019)
The deleterious rare alleles in NPL were associated with AoDILD. In addition, the deleterious rare allele frequency in the 9 candidate genes was also increased in AoDILD. The deleterious rare alleles might contribute to the pathogenesis of AoDILD.