Mesenchymal Stromal Cells Modulate Macrophages in Clinically Relevant Lung Injury Models by Extracellular Vesicle Mitochondrial Transfer.

Thomas J MorrisonMegan V JacksonErin K CunninghamAdrien KissenpfennigDaniel F McAuleyCecilia M O'KaneAnna D Krasnodembskaya

Published in: American journal of respiratory and critical care medicine (2017)

In the ARDS environment, MSCs promote an antiinflammatory and highly phagocytic macrophage phenotype through EV-mediated mitochondrial transfer. MSC-induced changes in macrophage phenotype critically depend on enhancement of macrophage oxidative phosphorylation. AMs treated with MSC-derived EVs ameliorate lung injury in vivo.

Keyphrases

adipose tissue
oxidative stress
mesenchymal stem cells
bone marrow
acute respiratory distress syndrome
intensive care unit
protein kinase
newly diagnosed
umbilical cord
electron transfer