Prognostic Role of Cell Blood Count in Chronic Myeloid Neoplasm and Acute Myeloid Leukemia and Its Possible Implications in Hematopoietic Stem Cell Transplantation.
Olga MulasBrunella MolaClelia MadedduGiovanni CaocciAntonio MacciòGiorgio La NasaPublished in: Diagnostics (Basel, Switzerland) (2022)
Numerous prognostic indexes have been developed in hematological diseases based on patient characteristics and genetic or molecular assessment. However, less attention was paid to more accessible parameters, such as neutrophils, lymphocytes, monocytes, and platelet counts. Although many studies have defined the role of neutrophil-to-lymphocyte or platelet-to-lymphocyte in lymphoid malignancies, few applications exist for myeloid neoplasm or hematopoietic stem cell transplantation procedures. In this review, we synthesized literature data on the prognostic value of count blood cells in myeloid malignancies and hematopoietic stem cell transplantation in the context of classical prognostic factors and clinical outcomes.
Keyphrases
- acute myeloid leukemia
- peripheral blood
- prognostic factors
- allogeneic hematopoietic stem cell transplantation
- induced apoptosis
- low grade
- systematic review
- dendritic cells
- single cell
- case report
- cell cycle arrest
- bone marrow
- working memory
- genome wide
- electronic health record
- cell therapy
- stem cells
- signaling pathway
- big data
- machine learning
- deep learning