Attrition-Enhanced Deracemization of the Antimalaria Drug Mefloquine.

Anthonius H J EngwerdaRick MaassenPaul Tinnemans Hugo Meekes Floris P J T Rutjes Elias Vlieg

Published in: Angewandte Chemie (International ed. in English) (2018)

Mefloquine is an important drug for prevention and treatment of malaria. It is commercially available as a racemic mixture, wherein only one enantiomer is active against malaria, while the other one causes severe psychotropic effects. By converting the drug into a compound that crystallizes as a racemizable racemic conglomerate, the deracemization of mefloquine into the desired enantiomer was achieved.

Keyphrases

drug induced
plasmodium falciparum
adverse drug
early onset