Ultrahigh-speed multimodal adaptive optics system for microscopic structural and functional imaging of the human retina.
Zhuolin LiuFuru ZhangKelvy ZuccaAnant AgrawalDaniel X HammerPublished in: Biomedical optics express (2022)
We describe the design and performance of a multimodal and multifunctional adaptive optics (AO) system that combines scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) for simultaneous retinal imaging at 13.4 Hz. The high-speed AO-OCT channel uses a 3.4 MHz Fourier-domain mode-locked (FDML) swept source. The system achieves exquisite resolution and sensitivity for pan-macular and transretinal visualization of retinal cells and structures while providing a functional assessment of the cone photoreceptors. The ultra-high speed also enables wide-field scans for clinical usability and angiography for vascular visualization. The FDA FDML-AO system is a powerful platform for studying various retinal and neurological diseases for vision science research, retina physiology investigation, and biomarker development.
Keyphrases
- optical coherence tomography
- high speed
- high resolution
- diabetic retinopathy
- optic nerve
- atomic force microscopy
- mass spectrometry
- induced apoptosis
- endothelial cells
- computed tomography
- pain management
- public health
- drug delivery
- cell cycle arrest
- healthcare
- health information
- single molecule
- cancer therapy
- high throughput
- electronic health record
- oxidative stress
- induced pluripotent stem cells
- signaling pathway
- social media
- magnetic resonance imaging
- brain injury
- cerebral ischemia
- cell proliferation
- fluorescence imaging
- metal organic framework