Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits.
Marie HanscomDavid J LoaneTaryn AubretchJenna LeserKara MolesworthNivedita HedgekarRodney M RitzelGelareh AbulwerdiTerez Shea-DonohueAlan I FadenPublished in: Journal of neuroinflammation (2021)
Intestinal inflammation during chronic experimental TBI causes a sustained systemic immune response and altered autonomic balance that are associated with microglial activation, increased neurodegeneration, and persistent neurological deficits.
Keyphrases
- traumatic brain injury
- immune response
- drug induced
- oxidative stress
- severe traumatic brain injury
- liver failure
- heart rate
- heart rate variability
- dendritic cells
- respiratory failure
- blood brain barrier
- high fat diet induced
- metabolic syndrome
- cerebral ischemia
- lps induced
- spinal cord injury
- toll like receptor
- ulcerative colitis
- spinal cord
- subarachnoid hemorrhage
- brain injury
- skeletal muscle