Course of the effects of LDL-cholesterol reduction on cardiovascular risk over time: A meta-analysis of 60 randomized controlled trials.
Pascal M BurgerJannick A N DorresteijnStefan KoudstaalJoris HoltropJohn J P KasteleinJ Wouter JukemaPaul M RidkerArend MosterdFrank L J VisserenPublished in: Atherosclerosis (2024)
Based on available RCT data with limited follow-up duration, the relative treatment effects of LDL-C reduction are stable over time in secondary prevention, but may attenuate with higher age in primary prevention.