Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the ARCTIC Study).
Iain Robert Louis KeanJohn Alexander ClarkZhenguang ZhangEsther DaubneyDeborah WhitePaloma Ferrando-VivasGema MillaBrian CuthbertsonJohn PappachanNigel KleinPaul MounceyKathy RowanJohn MyburghTheodore GouliourisStephen BakerJulian ParkhillNazima Pathannull Arctic Research TeamPublished in: Gut (2024)
Short interventions of SDD caused a shift in the microbiome but not of the AMR gene pool in critically ill children at the end mechanical ventilation, compared with standard antimicrobial therapy.
Keyphrases
- antimicrobial resistance
- mechanical ventilation
- acute respiratory distress syndrome
- intensive care unit
- study protocol
- staphylococcus aureus
- young adults
- physical activity
- climate change
- respiratory failure
- open label
- genome wide
- copy number
- stem cells
- extracorporeal membrane oxygenation
- clinical trial
- gene expression
- risk factors
- double blind