Weight gain as a predictor of frontal and temporal lobe volume loss in bipolar disorder: A prospective MRI study.
David J BondWayne SuWilliam G HonerTaj DhanoaTegan Batres-Y-CarrSusanne S LeeIvan J TorresRaymond W LamLakshmi N YathamPublished in: Bipolar disorders (2018)
These are the first prospective data on weight gain and neuroprogression in BDI. CSWG predicted neuroprogression, and neuroprogression predicted a worse clinical illness course. Trials of weight loss interventions are needed to confirm the causal direction of the weight gain-neuroprogression relationship, and to determine whether weight loss is a disease-modifying treatment.
Keyphrases
- weight gain
- weight loss
- bipolar disorder
- bariatric surgery
- birth weight
- roux en y gastric bypass
- body mass index
- gastric bypass
- major depressive disorder
- magnetic resonance imaging
- physical activity
- glycemic control
- electronic health record
- obese patients
- working memory
- functional connectivity
- adipose tissue
- big data
- combination therapy
- metabolic syndrome
- computed tomography
- skeletal muscle
- machine learning
- diffusion weighted imaging