Chitosan Oligosaccharide Lactate-Coated Ultrasmall Gadolinium Oxide Nanoparticles: Synthesis, In Vitro Cytotoxicity, and Relaxometric Properties.
Mohammad Yaseen AhmadMd Wasi AhmadHuan YueSon Long HoHyunsil ChaShanti MarasiniTirusew TegafawShuwen LiuAdibehalsadat GhazanfariKwon-Seok ChaeYongmin ChangGang Ho LeePublished in: Journal of nanoscience and nanotechnology (2021)
In this study, hydrophilic and biocompatible chitosan oligosaccharide lactate (COL)-coated ultra-small gadolinium oxide nanoparticles (NPs) were synthesized through a one-pot polyol method and characterized by various experimental techniques. The In Vitro cellular cytotoxicity assay indicated that the COL-coated gadolinium oxide NPs were non-toxic up to 500 μM Gd. In addition, their water proton spin relaxivities (i.e., r1 and r₂) were estimated to be 13.0 and 27.0 s-1mM-1, respectively, which are higher than those of commercial magnetic resonance imaging (MRI) contrast agents. The application potential of the solution sample as a T1 MRI contrast agent was demonstrated In Vitro by measuring map images in which dose-dependent contrast enhancements were observed.
Keyphrases
- oxide nanoparticles
- contrast enhanced
- magnetic resonance imaging
- magnetic resonance
- computed tomography
- diffusion weighted imaging
- drug delivery
- hyaluronic acid
- deep learning
- high throughput
- optical coherence tomography
- high resolution
- wound healing
- liquid chromatography
- convolutional neural network
- room temperature
- climate change
- density functional theory
- mass spectrometry
- risk assessment
- molecular dynamics
- single cell
- iron oxide nanoparticles
- iron oxide