Endothelial Protection in Lung Grafts through Heparanase Inhibition During Ex Vivo Lung Perfusion in Rats.
Kentaro NodaBrian J PhilipsNeha AtalePablo G SanchezPublished in: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (2023)
This study demonstrated that HPSE activity inhibition by SF4 can improve graft preservation during EVLP by protecting the glycocalyx and endothelial function, leading to better lung function following transplantation.