Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K-Akt signaling in gastric cancer.

Cheng ZhangMengqi ZhangSai GeWenwen HuangXiaoting LinJing GaoJifang GongLin Shen

Published in: Cancer medicine (2019)

Our work demonstrated that low-m6A signatures predicted adverse clinicopathological features of GC, while the reduction of RNA m6A methylation activated oncogenic Wnt/PI3K-Akt signaling and promoted malignant phenotypes of GC cells.

Keyphrases

pi k akt
cell cycle arrest
cell proliferation
signaling pathway
induced apoptosis
cell death
stem cells
genome wide
dna methylation
gas chromatography
transcription factor
emergency department
mass spectrometry
endoplasmic reticulum stress