Dysregulation of circulating collagen turnover markers in very early systemic sclerosis.

Rucsandra DobrotaSuzana JordanPernille JuhlNicoletta Del PapaBritta MaurerMike BeckerCarmen-Marina MihaiAnne-C Bay-JensenMorten Asser KarsdalAnne Sofie SiebuhrOliver Distler

Published in: RMD open (2024)

These findings indicate ECM remodelling as a very early phenomenon of SSc occurring in parallel with microvascular and autoimmune changes. Biomarkers of type III and IV collagens distinguished between veSSc patients and HC, indicating them as potential biomarkers for the detection of veSSc.

Keyphrases

systemic sclerosis
type iii
interstitial lung disease
end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
rheumatoid arthritis
extracellular matrix
postmenopausal women
label free