Efficacy and safety of methotrexate plus hydroxychloroquine combination therapy vs. methotrexate monotherapy in the treatment of rheumatoid arthritis: A randomized controlled clinical trial.
Jiasheng MaMiaoyu ZengChi-Jen HsuDandan LiMei Na FokYan JiangQiaoqiao LiJie MaJiaze ZhouBrian Shiian ChenFengju LiPublished in: International journal of rheumatic diseases (2024)
In our study, both the MTX + HCQ combination therapy and MTX monotherapy demonstrated improvements in symptoms, conditions and quality of life for patients with RA. Notably, the combination therapy could achieve better outcomes across all indices compared to MTX monotherapy, highlighting its potential as the optimal first-line treatment for RA. © 2024 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.
Keyphrases
- combination therapy
- rheumatoid arthritis
- disease activity
- high dose
- ankylosing spondylitis
- interstitial lung disease
- juvenile idiopathic arthritis
- systemic lupus erythematosus
- type diabetes
- clinical trial
- systemic sclerosis
- skeletal muscle
- physical activity
- study protocol
- weight loss
- glycemic control
- smoking cessation