Heading Tuning in Macaque Area V6.

To understand how we successfully navigate our world, it is important to understand which parts of the brain process cues used to perceive our direction of self-motion (i.e., heading). Cortical area V6 has been implicated in heading computations based on human neuroimaging data, but direct measurements of heading selectivity in individual V6 neurons have been lacking. We provide the first demonstration that V6 neurons carry 3D visual heading signals, which are represented in an eye-centered reference frame. In contrast, we found almost no evidence for vestibular heading signals in V6, indicating that V6 is unlikely to contribute to multisensory integration of heading signals, unlike other cortical areas. These findings provide important constraints on the roles of V6 in self-motion perception.