Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene.

Steven GazalKarim SacreYannick AllanoreMaria TeruelAlison H Goodallnull nullShigeto TohmaLars AlfredssonYukinori OkadaGang XieArnaud ConstantinAlejandro BalsaAya KawasakiPascale NicaiseChristopher AmosLuis Rodriguez-RodriguezGilles ChiocchiaCatherine BoileauJinyi ZhangOlivier VittecoqThomas BarnetcheMiguel A Gonzalez GayHiroshi FurukawaAlain CantagrelXavier Le LoëtTakayuki SumidaMargarita Hurtado-NedelecChristophe RichezSylvie Chollet-MartinThierry SchaeverbekeBernard CombeLiliane KhoryatiBaptiste CoustetJammel El-BennaKatherine SiminovitchRobert PlengeLeonid PadyukovJavier MartinNaoyuki TsuchiyaPhilippe Dieudé

Published in: Annals of the rheumatic diseases (2014)

We demonstrate a significant contribution of the combination of SPP1 rs11439060 and rs9138 frequent alleles to risk of RA, the magnitude of the association being greater in patients negative for ACPAs.

Keyphrases

rheumatoid arthritis
end stage renal disease
genome wide
copy number
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
genome wide identification
interstitial lung disease
gene expression
systemic lupus erythematosus
transcription factor
bioinformatics analysis
genome wide analysis