Excellent histological results in terms of articular cartilage regeneration after spheroid-based autologous chondrocyte implantation (ACI).

David GrevensteinAndreas MamilosVolker H SchmittTanja NiedermairWilli WagnerC James KirkpatrickChristoph Brochhausen

Published in: Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA (2020)

The present case series represents the first histological and immunohistological analyses of spheroid-based ACI in humans. Spheroid-based ACI revealed excellent histological results regarding the regeneration of hyaline articular cartilage. These results indicate that spheroid based ACI is a promising strategy for treating traumatic lesions of the articular cartilage of the knee.

Keyphrases

stem cells
spinal cord injury
total knee arthroplasty
cell therapy
single cell
knee osteoarthritis
wound healing
mesenchymal stem cells