Comparative analysis of human immune responses following SARS-CoV-2 vaccination with BNT162b2, mRNA-1273, or Ad26.COV2.S.
Dominique J BarbeauJudith M MartinEmily CarneyEmily DoughertyJoshua D DoyleTerence S DermodyAlejandro HobermanJohn V WilliamsMarian G MichaelsJohn F AlcornW Paul DuprexAnita K McElroyPublished in: NPJ vaccines (2022)
SARS-CoV-2 vaccines BNT162b2, mRNA-1273, and Ad26.COV2.S received emergency use authorization by the U.S. Food and Drug Administration in 2020/2021. Individuals being vaccinated were invited to participate in a prospective longitudinal comparative study of immune responses elicited by the three vaccines. In this observational cohort study, immune responses were evaluated using a SARS-CoV-2 spike protein receptor-binding domain ELISA, SARS-CoV-2 virus neutralization assays and an IFN- γ ELISPOT assay at various times over six months following initial vaccination. mRNA-based vaccines elicited higher magnitude humoral responses than Ad26.COV2.S; mRNA-1273 elicited the most durable humoral response, and all humoral responses waned over time. Neutralizing antibodies against the Delta variant were of lower magnitude than the wild-type strain for all three vaccines. mRNA-1273 initially elicited the greatest magnitude of T cell response, but this declined by 6 months. Declining immunity over time supports the use of booster dosing, especially in the setting of emerging variants.
Keyphrases
- sars cov
- immune response
- respiratory syndrome coronavirus
- binding protein
- dendritic cells
- wild type
- toll like receptor
- high throughput
- healthcare
- emergency department
- public health
- endothelial cells
- drug administration
- coronavirus disease
- small molecule
- gene expression
- risk assessment
- dna methylation
- zika virus
- protein protein
- dengue virus