Pancreatic loss of Mig6 alters murine endocrine cell fate and protects functional beta cell mass in an STZ-induced model of diabetes.

Brandon M BauerJose M IrimiaElizabeth Bloom-SaldanaJae-Wook Jeong Patrick T Fueger

Published in: bioRxiv : the preprint server for biology (2023)

Mig6 exerted differential effects on alpha and beta cell fate. Pancreatic loss of Mig6 reduced beta cell loss and promoted beta cell growth following STZ. Thus, suppression of Mig6 may provide relief of diabetes.

Keyphrases

cell fate
diabetic rats
type diabetes
single cell
cardiovascular disease
cell therapy
oxidative stress
glycemic control
stem cells
high glucose
metabolic syndrome
weight loss
skeletal muscle
adipose tissue
insulin resistance
endothelial cells