Caspase-1 activates gasdermin A in all non-mammals.

Zachary Paul BillmanStephen B KovacsBo WeiKidong KangOusmane H CisseEdward A Miao

Published in: bioRxiv : the preprint server for biology (2023)

We demonstrate that amphibians, reptiles and birds engage pyroptosis using caspase-1 and GS-DMA, filling an evolutionary gap in which caspase-1 cleaves GSDME in fish and GSDMD in mammals.

Keyphrases

cell death
induced apoptosis
endoplasmic reticulum stress
genome wide
signaling pathway
gene expression