Unraveling the Impact of Pneumococcal Conjugate Vaccines on Ambulatory Antibiotic Drug Consumption in Young Children: An Interrupted Time-Series Analysis.

Dana DaninoBart Adriaan van der BeekNoga Givon-LaviDavid GreenbergShalom Ben-ShimolRon Dagan

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

Shortly following PCV implementation, overall DAP rates showed an abrupt, steep decline, stabilizing within 5 years, in parallel to post-PCV respiratory infection trends previously described in this population, suggesting causality. The variable patterns of certain drug categories suggest additional influences beyond PCV.

Keyphrases

adverse drug
blood pressure
healthcare
drug induced
quality improvement
cancer therapy
drug delivery
respiratory tract
electronic health record